nmr lipoprofile testing lp4 algorithm  (LabCorp)

Journal: Biomedicines

Article Title: Comparison of Two Nuclear Magnetic Resonance Spectroscopy Methods for the Measurement of Lipoprotein Particle Concentrations

doi: 10.3390/biomedicines10071766

Figure Lengend Snippet: Mean concentrations of standard lipids and lipoprotein (sub)classes.

Article Snippet: The LabCorp Corp. (100 Perimeter Park, Morrisville, 27560 North Carolina, USA) performed NMR analysis using the NMR LipoProfile ® LP4 method (in the further text briefly lipoprofile) in Raleigh [ ].

Techniques:

Journal: Biomedicines

Article Title: Comparison of Two Nuclear Magnetic Resonance Spectroscopy Methods for the Measurement of Lipoprotein Particle Concentrations

doi: 10.3390/biomedicines10071766

Figure Lengend Snippet: Comparison of standard lipids between ß-quantification and lipofit NMR ( a ) and lipoprofile NMR ( b ). The ( a , b ) show the Passing–Bablok regression for total cholesterol (top left), triglycerides (top right), low-density lipoprotein cholesterol (bottom left), and high-density lipoprotein cholesterol (bottom right). The respective slopes of the regression lines (red) were 0.889 (TC), 1.027 (TG), 0.960 (LDL-C), and 0.830 (HDL-C) for lipofit and 0.914 (TC), 0.983 (TG), 0.973 (LDL-C), and 0.786 (HDL-C) for lipoprofile, respectively. The grey line represents the line of identity. (C = cholesterol. HDL = high-density lipoproteins. LDL = low-density lipoproteins. TC = total cholesterol. TG = triglycerides).

Article Snippet: The LabCorp Corp. (100 Perimeter Park, Morrisville, 27560 North Carolina, USA) performed NMR analysis using the NMR LipoProfile ® LP4 method (in the further text briefly lipoprofile) in Raleigh [ ].

Techniques: Comparison

Journal: Biomedicines

Article Title: Comparison of Two Nuclear Magnetic Resonance Spectroscopy Methods for the Measurement of Lipoprotein Particle Concentrations

doi: 10.3390/biomedicines10071766

Figure Lengend Snippet: Internal correlation matrix among lipids and lipoprotein particles for the lipoprofile method.

Article Snippet: The LabCorp Corp. (100 Perimeter Park, Morrisville, 27560 North Carolina, USA) performed NMR analysis using the NMR LipoProfile ® LP4 method (in the further text briefly lipoprofile) in Raleigh [ ].

Techniques:

Journal: Biomedicines

Article Title: Comparison of Two Nuclear Magnetic Resonance Spectroscopy Methods for the Measurement of Lipoprotein Particle Concentrations

doi: 10.3390/biomedicines10071766

Figure Lengend Snippet: Comparison of lipoprotein particles between the lipoprofile NMR and lipofit NMR methods. The figures show the Passing–Bablok regression for LDL-p (top left ), LDL-s (top right), HDL-p (bottom left, and HDL-s (bottom right ). The respective slopes of the regression lines (red) were 1.057 (LDL-p), 0.860 (LDL-s), 1.637 (HDL-p), and 1.014 (HDL-s), respectively. The grey line represents the line of identity. (HDL = high-density lipoproteins. LDL = low-density lipoproteins. p = particles. s = size).

Article Snippet: The LabCorp Corp. (100 Perimeter Park, Morrisville, 27560 North Carolina, USA) performed NMR analysis using the NMR LipoProfile ® LP4 method (in the further text briefly lipoprofile) in Raleigh [ ].

Techniques: Comparison

Journal: Biomedicines

Article Title: Comparison of Two Nuclear Magnetic Resonance Spectroscopy Methods for the Measurement of Lipoprotein Particle Concentrations

doi: 10.3390/biomedicines10071766

Figure Lengend Snippet: Comparison of lipoprotein particles between the lipoprofile and lipofit methods. The figures show the Passing–Bablok regression for large and very large VLDL (top left ), LDL-p (top middle), LDL-s (top right ), large LDL-p (middle left ), small and medium LDL-p ( middle ), HDL-p (middle right), HDL-s (bottom left ), large HDL-p (bottom middle), and small HDL-p (bottom right ). The respective slopes of the regression lines (red) were 0.980 (large VLDL-p), 1.272 (large LDL-p), 0.593 (small and medium LDL-p), 1.817 (small HDL-p) and 1.722 (large HDL-p), respectively. The grey line represents the line of identity. (HDL = high-density lipoproteins. LDL = low-density lipoproteins. p = particles. VLDL = very-low-density lipoproteins).

Article Snippet: The LabCorp Corp. (100 Perimeter Park, Morrisville, 27560 North Carolina, USA) performed NMR analysis using the NMR LipoProfile ® LP4 method (in the further text briefly lipoprofile) in Raleigh [ ].

Techniques: Comparison

Journal: Methodist DeBakey Cardiovascular Journal

Article Title: High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes

doi: 10.14797/mdcj-15-1-55

Figure Lengend Snippet: The relationship between size exclusion chromatography and nuclear magnetic resonance (NMR) spectroscopy. Plasma was separated by size exclusion chromatography. Choline-containing phospholipid was quantified in each fraction using a kit from Wako. Eluted fractions were also quantified by NMR spectroscopy at LabCorp (formerly LipoScience) using an optimized version (LP4) of NMR LipoProfile. The average size particles from each of the gel filtration fraction quantified by NMR is shown in the table to the right and are consistent with those obtained by NMR. LDL: low-density lipoprotein; VLDL: very low-density lipoprotein; HDL: high-density lipoprotein; FPLC: fast protein liquid chromatography

Article Snippet: Eluted fractions were also quantified by NMR spectroscopy at LabCorp (formerly LipoScience) using an optimized version (LP4) of NMR LipoProfile.

Techniques: Size-exclusion Chromatography, Nuclear Magnetic Resonance, Structural Proteomics, Clinical Proteomics, Filtration, Fast Protein Liquid Chromatography